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Dairy products such as fish, milk, poultry, eggs, and meat are the main sources of B12

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The Bliss synergy score was therefore calculated as follows: In this context, a positive Bliss score means that the observed effect of the combination is lower than what would be anticipated if the drug effects were independent, thereby indicating synergy

In addition, berberine is small in size, so it can available through the blood-brain barrier and effectually act on molecular target, showing great therapeutic potential in the treatment of neurodegenerative diseases (Wang et al., 2005

Pravat K Mandal, Anshika Goel, Ashley I Bush, Khushboo Punjabi, Shallu Joon, Ritwick Mishra, Manjari Tripathi, Arun Garg, Natasha K Kumar, Pooja Sharma, Deepika Shukla, Scott Jonathan Ayton, Amir Fazlollahi, Joseph C Maroon, Divya Dwivedi, Avantika Samkaria, Kanika Sandal, Kanu Megha, Sandhya Shandilya, Hippocampal glutathione depletion with enhanced iron level in patients with mild cognitive impairment and Alzheimers disease compared with healthy elderly participants, Brain Communications, Volume 4, Issue 5, 2022, fcac215, Watanabe F, Hashizume E, Chan GP, Kamimura A

Georgiev V.G., Weber J., Kneschke E.M., Denev P.N., Bley T., Pavlov A.I